POLYETHYLENE GLYCOL CONJUGATES OF PACLITAXEL AS PRODRUGS BY SIMPLE TECHNIQUE SUCH AS SOLVENT EVAPORATION
نویسندگان
چکیده
منابع مشابه
Polyethylene glycol as a cause of anaphylaxis
BACKGROUND Polyethylene glycols (PEGs) or macrogols are polyether compounds and are widely used as additives in pharmaceuticals, cosmetics, and food. CASE REPORT We report on a Caucasian patient experiencing recurrent severe allergic reactions to several drugs. An extensive diagnostic workup including skin prick tests, intradermal tests (IDT) and a double-blind oral challenge was performed to...
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Polyethylene glycols (PEG 200-7(0) are used as solvents in various pharmaceutical preparations meant for both internal and external use (1,2). PEGs are incompatible with iodine, potassium iodide, sorbitol, tannic acid, metallic salts like bismuth, mercury and silver salts (2). Their systemic absorption in certain conditions may result in renal failure and CNS depression (3). Morbidity has been ...
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One approach for the enhancement of oral drug bioavailability is the technique of nanoparticle preparation. Risedronate sodium (Biopharmaceutical Classification System Class III) was chosen as a model compound with high water solubility and low intestinal permeability. Eighteen samples of risedronate sodium were prepared by the solvent evaporation technique with sodium dodecyl sulfate, polysorb...
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ژورنال
عنوان ژورنال: International Research Journal of Pharmacy
سال: 2017
ISSN: 2230-8407
DOI: 10.7897/2230-8407.086106